Tugain 10 is a minoxidil 10% topical solution used to prevent hair loss caused by male pattern baldness. It is a vasodilator that works by relaxing blood vessels in the scalp to increase circulation and stimulate the hair follicles preventing further loss of hair. Prolonged use may also cause the growth of new hair.
General information about Tugain 10 (Minoxidil 10%)
Tugain 10 is manufactured by Cipla (India). Cipla has an international GMP (Good Manufacturing Practice) certificate. GMP certificate - evidence of a high level of production and quality of manufactured drugs.
Cipla was founded as 'The Chemical, Industrial & Pharmaceutical Laboratories' in 1935 in Mumbai. The name of the company was changed to 'Cipla Limited' on 20 July 1984. In the year 1985, the US FDA approved the company's bulk drug manufacturing facilities. Cipla Ltd. has become one of the leaders in the pharmaceutical market in India.
Tugain 10 solution contains minoxidil 10%, when applied topically, should stimulate hair growth in individuals with androgenetic alopecia (male pattern baldness).
Chemically, minoxidil is 2,4-diamino-6-piperidinopyrimidine-3-oxide.
When applied topically, minoxidil solution for external use has been shown to stimulate hair growth in individuals with androgenetic alopecia (male pattern baldness). Although the exact mechanisms of action of minoxidil in the treatment of androgenetic alopecia are not known, there may be several ways this drug can stimulate hair growth. These include:
- Vasodilation of the microvasculature around the hair follicles, which enhances hair growth;
- Direct stimulation of hair follicle cells, which induces them to enter the proliferative phase: follicles in the resting phase (telogen) enter the active phase (anagen);
- Disruption of the effect of androgens on genetically predisposed hair follicles: Minoxidil can interfere with androgen metabolism in the scalp, suppressing the ability of androgens to act on hair follicles.
Clinical studies conducted with minoxidil solution show that the expected stimulation of hair growth may require application of the drug for 4 months or more. The duration of the onset of drug action and the degree of its activity may differ among patients. Discontinuation of topical minoxidil solution usually returns to baseline after 3-4 months.
Packaging form, composition and dosage of Minoxidil 10% Tugain 10
Tugain 10 comes in lotion form. One bottle contains 60 ml of the drug and is designed for 1 month of use.
Tugain 10 kit includes pipette and spray.
Each ml of solution contains:
- Minoxidil IP (International Pharmacopoeia) - 10.0% (by weight)
- Absolute Alcohol - 40.0% (by volume)
Indications for the use of Minoxidil 10% Tugain 10
Tugain 10 is used to treat androgenetic alopecia (male pattern baldness) in men aged from 18 to 60 years old. Not for use by women.
Warnings and special instructions for using Minoxidil Tugain 10
Some absorption of minoxidil from the skin surface creates the possibility of developing systemic effects such as tachycardia, angina pectoris and edema, and an increased likelihood of orthostatic hypotension caused by guanethidine. Patients should be monitored dynamically to identify possible systemic effects of minoxidil. If systemic side effects appear, the drug should be discontinued. If necessary, diuretic drugs should be used to treat fluid retention and edema. Control of tachycardia and angina pectoris is possible with the prescription of drugs from the group of beta-blockers or other inhibitors of the activity of the sympathetic nervous system.
Childhood: The safety and efficacy of Tugain 10 in patients under 18 years of age has not been established.
Use in patients with concomitant cardiovascular disease: Minoxidil Topical Solution should not be used in patients with known concurrent coronary artery disease, cardiac arrhythmias, congestive heart failure, or valvular heart disease. Patients with hypertension, including those receiving antihypertensive drugs, should be closely monitored. If necessary, it is necessary to correct the treatment. If the patient has any other cardiovascular disease, Tugain 10 should be used with caution.
Elderly use: No studies have been performed with people over the age of 60. Therefore, the safety and efficacy of Tugain 10 has not been identified in these patients.
How to use Minoxidil 10% Tugain 10
Tugain 10 Topical Solution, in a total amount of 1 ml, should be applied once or twice (as prescribed by a doctor) daily to thinning scalp areas starting from the center of the affected area. Regardless of the size of the affected area, this dose must be used. The total daily dose of the drug should not exceed 2 ml. Tugain 10 Topical Solution should only be applied to completely dry hair and scalp.